Shapes of Molecules

  1. You may have noticed that sometimes there are multiple ways to construct a molecule from the atoms given in the formula. Take C4H10 for example :
    n-butane
    iso-butane (2-methypropane)
  2. Each of the compounds displayed above is an isomer of butane. Isomers refer to different molecules with the same formula.
  3. Click here to check out the Isomer Construction Set by Fred Senese at Frostburg State.
  4. Did you notice that the molecules shown above have a particular shape to them?
  5. Molecules will form into shapes such that regions of high electron density (where electrons are being shared between atoms and where there are unshared pairs of valence electrons on the surface).
  6. Because all of these regions are negatively charged, they repel each other and try to move as far away as possible from each other.
  7. Depending on how many atoms are bonded and if there are unshared pairs of electrons around, you will see the following common shapes:
Tetrahedral
Trigonal Pyramidal
Trigonal Planar
Bent
Linear
  1. Check out the images of molecules below and see where you can find these shapes within them. The images are being displayed by the Chime plug-in which allows you to manipulate and take measurements on the displayed molecules. See the Using the Chime Plug-in sheet for instructions.
  2. Click here to bring up a page that contains several molecules for you to explore using the Exploring Molecular Shapes guide.
  3. The shape of molecules is extremely important, especially for larger more complex molecules. Below are several examples showing how shape is the key factor in a molecules biological function.
    1. Immune function: Our immune system has the capability to recognize foreign material that enters our body. It does this not by "thinking" about it. After the first time our immune system encounters a pathogen, it makes antibodies that are just the right shape to bond with the foreign antigen. Below is an example showing the antibody molecule in green and the antigen in red:

      Hide/Show the antigen.
  4. The synthesis of ATP (the primary energy storing molecule in our body) happens in a series of steps using ATP synthase.
    1. Film: See the entire ATP Synthase enzyme at work.
    2. Film: Focus on the active region.
  5. Click here to see how some molecules can change shape in order to better fit with another molecule.

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